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Inhibition of poly(ADP-ribose) polymerase-1 attenuates the toxicity of carbon tetrachloride
Carbon tetrachloride (CCl(4)) is routinely used as a model compound for eliciting centrilobular hepatotoxicity. It can be bioactivated to the trichloromethyl radical, which causes extensive lipid peroxidation and ultimately cell death by necrosis. Overactivation of poly(ADP-ribose) polymerase-1 (PAR...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Informa Healthcare
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3296519/ https://ncbi.nlm.nih.gov/pubmed/21395487 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/14756366.2011.557315 |
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