Inhibition of poly(ADP-ribose) polymerase-1 attenuates the toxicity of carbon tetrachloride

Carbon tetrachloride (CCl(4)) is routinely used as a model compound for eliciting centrilobular hepatotoxicity. It can be bioactivated to the trichloromethyl radical, which causes extensive lipid peroxidation and ultimately cell death by necrosis. Overactivation of poly(ADP-ribose) polymerase-1 (PAR...

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Autores principales: Banasik, Marek, Stedeford, Todd, Strosznajder, Robert P, Takehashi, Masanori, Tanaka, Seigo, Ueda, Kunihiro
Formato: Artigo
Lenguaje:Inglês
Publicado: Informa Healthcare 2011
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3296519/
https://ncbi.nlm.nih.gov/pubmed/21395487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/14756366.2011.557315
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