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Overexpression of CYP2D6 Attenuates the Toxicity of MPP(+) in Actively Dividing and Differentiated PC12 Cells
Clonal pheochromocytoma cell lines overexpressing cytochrome P450 2D6 (CYP2D6) were established. CYP2D6 was localized in the endoplasmic reticulum, and its enzymatic activity in the microsomal fraction was confirmed by using high performance liquid chromatography analysis with [guanidine-(14)C]debri...
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| Publicado no: | Gene Expr |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cognizant Communication Corporation
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5991163/ https://ncbi.nlm.nih.gov/pubmed/14686785 |
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