Overexpression of CYP2D6 Attenuates the Toxicity of MPP(+) in Actively Dividing and Differentiated PC12 Cells

Clonal pheochromocytoma cell lines overexpressing cytochrome P450 2D6 (CYP2D6) were established. CYP2D6 was localized in the endoplasmic reticulum, and its enzymatic activity in the microsomal fraction was confirmed by using high performance liquid chromatography analysis with [guanidine-(14)C]debri...

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Detaylı Bibliyografya
Yayımlandı:Gene Expr
Asıl Yazarlar: Matoh, Naomi, Tanaka, Seigo, Takehashi, Masanori, Banasik, Marek, Stedeford, Todd, Masliah, Eliezer, Suzuki, Shigehiko, Nishimura, Yoshihiko, Ueda, Kunihiro
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Cognizant Communication Corporation 2018
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5991163/
https://ncbi.nlm.nih.gov/pubmed/14686785
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