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Inhibition of Poly(ADP-ribose) Polymerase-1 Enhances Gene Expression of Selected Sirtuins and APP Cleaving Enzymes in Amyloid Beta Cytotoxicity

Poly(ADP-ribose) polymerases (PARPs) and sirtuins (SIRTs) are involved in the regulation of cell metabolism, transcription, and DNA repair. Alterations of these enzymes may play a crucial role in Alzheimer’s disease (AD). Our previous results indicated that amyloid beta (Aβ) peptides and inflammatio...

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Detalles Bibliográficos
Publicado en:Mol Neurobiol
Main Authors: Wencel, Przemysław L., Lukiw, Walter J., Strosznajder, Joanna B., Strosznajder, Robert Piotr
Formato: Artigo
Idioma:Inglês
Publicado: Springer US 2017
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5948241/
https://ncbi.nlm.nih.gov/pubmed/28698968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12035-017-0646-8
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