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Microtubule assembly governed by tubulin allosteric gain in flexibility and lattice induced fit

Microtubules (MTs) are key components of the cytoskeleton and play a central role in cell division and development. MT assembly is known to be associated with a structural change in [Formula: see text]-tubulin dimers from kinked to straight conformations. How GTP binding renders individual dimers po...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:eLife
Prif Awduron: Igaev, Maxim, Grubmüller, Helmut
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: eLife Sciences Publications, Ltd 2018
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5945277/
https://ncbi.nlm.nih.gov/pubmed/29652248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.34353
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