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A mutation uncouples the tubulin conformational and GTPase cycles, revealing allosteric control of microtubule dynamics
Microtubule dynamic instability depends on the GTPase activity of the polymerizing αβ-tubulin subunits, which cycle through at least three distinct conformations as they move into and out of microtubules. How this conformational cycle contributes to microtubule growing, shrinking, and switching rema...
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| Publicado no: | eLife |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
eLife Sciences Publications, Ltd
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4728127/ https://ncbi.nlm.nih.gov/pubmed/26439009 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.10113 |
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