A mutation uncouples the tubulin conformational and GTPase cycles, revealing allosteric control of microtubule dynamics

Microtubule dynamic instability depends on the GTPase activity of the polymerizing αβ-tubulin subunits, which cycle through at least three distinct conformations as they move into and out of microtubules. How this conformational cycle contributes to microtubule growing, shrinking, and switching rema...

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Publicat a:eLife
Autors principals: Geyer, Elisabeth A, Burns, Alexander, Lalonde, Beth A, Ye, Xuecheng, Piedra, Felipe-Andres, Huffaker, Tim C, Rice, Luke M
Format: Artigo
Idioma:Inglês
Publicat: eLife Sciences Publications, Ltd 2015
Matèries:
Biophysics and Structural Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4728127/
https://ncbi.nlm.nih.gov/pubmed/26439009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.10113
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