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GDP-to-GTP exchange on the microtubule end can contribute to the frequency of catastrophe

Microtubules are dynamic polymers of αβ-tubulin that have essential roles in chromosome segregation and organization of the cytoplasm. Catastrophe—the switch from growing to shrinking—occurs when a microtubule loses its stabilizing GTP cap. Recent evidence indicates that the nucleotide on the microt...

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Detalhes bibliográficos
Publicado no:Mol Biol Cell
Main Authors: Piedra, Felipe-Andrés, Kim, Tae, Garza, Emily S., Geyer, Elisabeth A., Burns, Alexander, Ye, Xuecheng, Rice, Luke M.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Cell Biology 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5221584/
https://ncbi.nlm.nih.gov/pubmed/27146111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E16-03-0199
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