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Direct observation of individual tubulin dimers binding to growing microtubules

The biochemical basis of microtubule growth has remained elusive for over 30 years despite being fundamental for both cell division and associated chemotherapy strategies. Here, we combine interferometric scattering microscopy with recombinant tubulin to monitor individual tubulins binding to and di...

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Bibliografski detalji
Izdano u:Proc Natl Acad Sci U S A
Glavni autori: Mickolajczyk, Keith J., Geyer, Elisabeth A., Kim, Tae, Rice, Luke M., Hancock, William O.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2019
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6462098/
https://ncbi.nlm.nih.gov/pubmed/30804205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1815823116
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