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Direct observation of individual tubulin dimers binding to growing microtubules

The biochemical basis of microtubule growth has remained elusive for over 30 years despite being fundamental for both cell division and associated chemotherapy strategies. Here, we combine interferometric scattering microscopy with recombinant tubulin to monitor individual tubulins binding to and di...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Mickolajczyk, Keith J., Geyer, Elisabeth A., Kim, Tae, Rice, Luke M., Hancock, William O.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2019
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6462098/
https://ncbi.nlm.nih.gov/pubmed/30804205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1815823116
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