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The lattice as allosteric effector: Structural studies of αβ- and γ-tubulin clarify the role of GTP in microtubule assembly

GTP-dependent microtubule polymerization dynamics are required for cell division and are accompanied by domain rearrangements in the polymerizing subunit, αβ-tubulin. Two opposing models describe the role of GTP and its relationship to conformational change in αβ-tubulin. The allosteric model posits...

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Bibliografiske detaljer
Main Authors: Rice, Luke M., Montabana, Elizabeth A., Agard, David A.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2291134/
https://ncbi.nlm.nih.gov/pubmed/18388201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0801155105
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