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The lattice as allosteric effector: Structural studies of αβ- and γ-tubulin clarify the role of GTP in microtubule assembly
GTP-dependent microtubule polymerization dynamics are required for cell division and are accompanied by domain rearrangements in the polymerizing subunit, αβ-tubulin. Two opposing models describe the role of GTP and its relationship to conformational change in αβ-tubulin. The allosteric model posits...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2291134/ https://ncbi.nlm.nih.gov/pubmed/18388201 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0801155105 |
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