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Severing enzymes amplify microtubule arrays through lattice GTP-tubulin incorporation
Spastin and katanin sever and destabilize microtubules. Paradoxically, despite their destructive activity they increase microtubule mass in vivo. Here we combine single-molecule fluorescence total internal reflection and electron microscopy to show that the elemental step in microtubule-severing was...
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| Gepubliceerd in: | Science |
|---|---|
| Hoofdauteurs: | , , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2018
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6510489/ https://ncbi.nlm.nih.gov/pubmed/30139843 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aau1504 |
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