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Katanin grips the β-tubulin tail through an electropositive double spiral to sever microtubules
The AAA ATPase katanin severs microtubules. It is critical in cell division, centriole biogenesis and neuronal morphogenesis. Its mutation causes microcephaly. The microtubule templates katanin hexamerization and activates its ATPase. The structural basis for these activities and how they lead to se...
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| Published in: | Dev Cell |
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| Main Authors: | , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2019
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7060837/ https://ncbi.nlm.nih.gov/pubmed/31735665 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2019.10.010 |
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