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Katanin grips the β-tubulin tail through an electropositive double spiral to sever microtubules

The AAA ATPase katanin severs microtubules. It is critical in cell division, centriole biogenesis and neuronal morphogenesis. Its mutation causes microcephaly. The microtubule templates katanin hexamerization and activates its ATPase. The structural basis for these activities and how they lead to se...

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Bibliographic Details
Published in:Dev Cell
Main Authors: Zehr, Elena A., Szyk, Agnieszka, Szczesna, Ewa, Roll-Mecak, Antonina
Format: Artigo
Language:Inglês
Published: 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7060837/
https://ncbi.nlm.nih.gov/pubmed/31735665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2019.10.010
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