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High resolution microtubule structures reveal the structural transitions in αβ–tubulin upon GTP hydrolysis
Dynamic instability, the stochastic switching between growth and shrinkage, is essential for microtubule function. This behavior is driven by GTP hydrolysis in the microtubule lattice, and is inhibited by anticancer agents like Taxol. We provide new insight into the mechanism of dynamic instability,...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2014
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4054694/ https://ncbi.nlm.nih.gov/pubmed/24855948 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.03.053 |
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