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High resolution microtubule structures reveal the structural transitions in αβ–tubulin upon GTP hydrolysis

Dynamic instability, the stochastic switching between growth and shrinkage, is essential for microtubule function. This behavior is driven by GTP hydrolysis in the microtubule lattice, and is inhibited by anticancer agents like Taxol. We provide new insight into the mechanism of dynamic instability,...

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Detalhes bibliográficos
Main Authors: Alushin, Gregory M., Lander, Gabriel C., Kellogg, Elizabeth H., Zhang, Rui, Baker, David, Nogales, Eva
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4054694/
https://ncbi.nlm.nih.gov/pubmed/24855948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.03.053
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