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Proteostasis in Huntington's disease: disease mechanisms and therapeutic opportunities
Many neurodegenerative diseases are characterized by impairment of protein quality control mechanisms in neuronal cells. Ineffective clearance of misfolded proteins by the proteasome, autophagy pathways and exocytosis leads to accumulation of toxic protein oligomers and aggregates in neurons. Toxic...
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| 發表在: | Acta Pharmacol Sin |
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| Main Authors: | , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Nature Publishing Group
2018
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5943907/ https://ncbi.nlm.nih.gov/pubmed/29620053 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2018.11 |
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