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Huntington’s Disease: Mechanisms of Pathogenesis and Therapeutic Strategies

Huntington's disease is a late-onset neurodegenerative disease caused by a CAG trinucleotide repeat in the gene encoding the huntingtin protein. Despite its well-defined genetic origin, the molecular and cellular mechanisms underlying the disease are unclear and complex. Here, we review some of...

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Detalhes bibliográficos
Publicado no:Cold Spring Harb Perspect Med
Main Authors: Jimenez-Sanchez, Maria, Licitra, Floriana, Underwood, Benjamin R., Rubinsztein, David C.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5495055/
https://ncbi.nlm.nih.gov/pubmed/27940602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/cshperspect.a024240
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