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Proteostasis in Huntington's disease: disease mechanisms and therapeutic opportunities
Many neurodegenerative diseases are characterized by impairment of protein quality control mechanisms in neuronal cells. Ineffective clearance of misfolded proteins by the proteasome, autophagy pathways and exocytosis leads to accumulation of toxic protein oligomers and aggregates in neurons. Toxic...
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| Publicat a: | Acta Pharmacol Sin |
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| Autors principals: | , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group
2018
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5943907/ https://ncbi.nlm.nih.gov/pubmed/29620053 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2018.11 |
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