White matter hyperintensities and the mediating role of cerebral amyloid angiopathy in dominantly-inherited Alzheimer’s disease

INTRODUCTION: White matter hyperintensity (WMH) volume on MRI is increased among presymptomatic individuals with autosomal dominant mutations for Alzheimer’s disease (AD). One potential explanation is that WMH, conventionally considered a marker of cerebrovascular disease, are a reflection of cerebr...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Lee, Seonjoo, Zimmerman, Molly E., Narkhede, Atul, Nasrabady, Sara E., Tosto, Giuseppe, Meier, Irene B., Benzinger, Tammie L. S., Marcus, Daniel S., Fagan, Anne M., Fox, Nick C., Cairns, Nigel J., Holtzman, David M., Buckles, Virginia, Ghetti, Bernardino, McDade, Eric, Martins, Ralph N., Saykin, Andrew J., Masters, Colin L., Ringman, John M., Fӧrster, Stefan, Schofield, Peter R., Sperling, Reisa A., Johnson, Keith A., Chhatwal, Jasmeer P., Salloway, Stephen, Correia, Stephen, Jack, Clifford R., Weiner, Michael, Bateman, Randall J., Morris, John C., Mayeux, Richard, Brickman, Adam M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5942789/
https://ncbi.nlm.nih.gov/pubmed/29742105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0195838
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