Longitudinal change in CSF biomarkers in autosomal-dominant Alzheimer disease

Clinicopathologic evidence suggests the pathology of Alzheimer disease (AD) begins many years prior to cognitive symptoms. Biomarkers are required to identify affected individuals during this asymptomatic (“pre-clinical”) stage to permit intervention with potential disease-modifying therapies design...

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Main Authors: Fagan, Anne M., Xiong, Chengjie, Jasielec, Mateusz S., Bateman, Randall J., Goate, Alison M., Benzinger, Tammie L.S., Ghetti, Bernardino, Martins, Ralph N., Masters, Colin L., Mayeux, Richard, Ringman, John M., Rossor, Martin N., Salloway, Stephen, Schofield, Peter R., Sperling, Reisa A., Marcus, Daniel, Cairns, Nigel J., Buckles, Virginia D., Ladenson, Jack H., Morris, John C., Holtzman, David M.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4038930/
https://ncbi.nlm.nih.gov/pubmed/24598588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3007901
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