Longitudinal change in CSF biomarkers in autosomal-dominant Alzheimer disease

Clinicopathologic evidence suggests the pathology of Alzheimer disease (AD) begins many years prior to cognitive symptoms. Biomarkers are required to identify affected individuals during this asymptomatic (“pre-clinical”) stage to permit intervention with potential disease-modifying therapies design...

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Detalhes bibliográficos
Main Authors: Fagan, Anne M., Xiong, Chengjie, Jasielec, Mateusz S., Bateman, Randall J., Goate, Alison M., Benzinger, Tammie L.S., Ghetti, Bernardino, Martins, Ralph N., Masters, Colin L., Mayeux, Richard, Ringman, John M., Rossor, Martin N., Salloway, Stephen, Schofield, Peter R., Sperling, Reisa A., Marcus, Daniel, Cairns, Nigel J., Buckles, Virginia D., Ladenson, Jack H., Morris, John C., Holtzman, David M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4038930/
https://ncbi.nlm.nih.gov/pubmed/24598588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3007901
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