Φορτώνει......
Mutations in the promoter of the telomerase gene TERT contribute to tumorigenesis by a two-step mechanism
TERT promoter mutations (TPMs) are the most common non-coding mutations in cancer. The timing and consequences of TPMs have not been fully established. Here we show that TPMs acquired at the transition from benign nevus to malignant melanoma do not support telomere maintenance. In vitro experiments...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | Science |
|---|---|
| Κύριοι συγγραφείς: | , , , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2017
|
| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5942222/ https://ncbi.nlm.nih.gov/pubmed/28818973 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aao0535 |
| Ετικέτες: |
Προσθήκη ετικέτας
Δεν υπάρχουν, Καταχωρήστε ετικέτα πρώτοι!
|