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Cancer-associated TERT promoter mutations abrogate telomerase silencing
Mutations in the human telomerase reverse transcriptase (TERT) promoter are the most frequent non-coding mutations in cancer, but their molecular mechanism in tumorigenesis has not been established. We used genome editing of human pluripotent stem cells with physiological telomerase expression to el...
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| Publicado no: | eLife |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
eLife Sciences Publications, Ltd
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4507476/ https://ncbi.nlm.nih.gov/pubmed/26194807 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.07918 |
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