Mutations in the promoter of the telomerase gene TERT contribute to tumorigenesis by a two-step mechanism

TERT promoter mutations (TPMs) are the most common non-coding mutations in cancer. The timing and consequences of TPMs have not been fully established. Here we show that TPMs acquired at the transition from benign nevus to malignant melanoma do not support telomere maintenance. In vitro experiments...

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Publicado no:Science
Main Authors: Chiba, Kunitoshi, Lorbeer, Franziska K., Shain, A. Hunter, McSwiggen, David T., Schruf, Eva, Oh, Areum, Ryu, Jekwan, Darzacq, Xavier, Bastian, Boris C., Hockemeyer, Dirk
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5942222/
https://ncbi.nlm.nih.gov/pubmed/28818973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aao0535
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