Endogenous Telomerase Reverse Transcriptase N-Terminal Tagging Affects Human Telomerase Function at Telomeres In Vivo

Telomerase action at telomeres is essential for the immortal phenotype of stem cells and the aberrant proliferative potential of cancer cells. Insufficient telomere maintenance can cause stem cell and tissue failure syndromes, while increased telomerase levels are associated with tumorigenesis. Both...

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Publicado en:Mol Cell Biol
Autores principales: Chiba, Kunitoshi, Vogan, Jacob M., Wu, Robert A., Gill, Manraj S., Zhang, Xiaozhu, Collins, Kathleen, Hockemeyer, Dirk
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2017
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5247607/
https://ncbi.nlm.nih.gov/pubmed/27872149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00541-16
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