Endogenous Telomerase Reverse Transcriptase N-Terminal Tagging Affects Human Telomerase Function at Telomeres In Vivo

Telomerase action at telomeres is essential for the immortal phenotype of stem cells and the aberrant proliferative potential of cancer cells. Insufficient telomere maintenance can cause stem cell and tissue failure syndromes, while increased telomerase levels are associated with tumorigenesis. Both...

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Detalhes bibliográficos
Publicado no:Mol Cell Biol
Main Authors: Chiba, Kunitoshi, Vogan, Jacob M., Wu, Robert A., Gill, Manraj S., Zhang, Xiaozhu, Collins, Kathleen, Hockemeyer, Dirk
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5247607/
https://ncbi.nlm.nih.gov/pubmed/27872149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00541-16
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