Endogenous Telomerase Reverse Transcriptase N-Terminal Tagging Affects Human Telomerase Function at Telomeres In Vivo

Telomerase action at telomeres is essential for the immortal phenotype of stem cells and the aberrant proliferative potential of cancer cells. Insufficient telomere maintenance can cause stem cell and tissue failure syndromes, while increased telomerase levels are associated with tumorigenesis. Both...

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Publicat a:Mol Cell Biol
Autors principals: Chiba, Kunitoshi, Vogan, Jacob M., Wu, Robert A., Gill, Manraj S., Zhang, Xiaozhu, Collins, Kathleen, Hockemeyer, Dirk
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2017
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5247607/
https://ncbi.nlm.nih.gov/pubmed/27872149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00541-16
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