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Transient activation of the UPR(ER) is an essential step in the acquisition of pluripotency during reprogramming

Somatic cells can be reprogrammed into pluripotent stem cells using the Yamanaka transcription factors. Reprogramming requires both epigenetic landscape reshaping and global remodeling of cell identity, structure, basic metabolic processes, and organelle form and function. We hypothesize that variab...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Simic, Milos S., Moehle, Erica A., Schinzel, Robert T., Lorbeer, Franziska K., Halloran, Jonathan J., Heydari, Kartoosh, Sanchez, Melissa, Jullié, Damien, Hockemeyer, Dirk, Dillin, Andrew
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6457941/
https://ncbi.nlm.nih.gov/pubmed/30989118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aaw0025
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