Transient activation of the UPR(ER) is an essential step in the acquisition of pluripotency during reprogramming

Somatic cells can be reprogrammed into pluripotent stem cells using the Yamanaka transcription factors. Reprogramming requires both epigenetic landscape reshaping and global remodeling of cell identity, structure, basic metabolic processes, and organelle form and function. We hypothesize that variab...

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發表在:Sci Adv
Main Authors: Simic, Milos S., Moehle, Erica A., Schinzel, Robert T., Lorbeer, Franziska K., Halloran, Jonathan J., Heydari, Kartoosh, Sanchez, Melissa, Jullié, Damien, Hockemeyer, Dirk, Dillin, Andrew
格式: Artigo
語言:Inglês
出版: American Association for the Advancement of Science 2019
主題:
Research Articles
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6457941/
https://ncbi.nlm.nih.gov/pubmed/30989118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aaw0025
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