Transient activation of the UPR(ER) is an essential step in the acquisition of pluripotency during reprogramming

Somatic cells can be reprogrammed into pluripotent stem cells using the Yamanaka transcription factors. Reprogramming requires both epigenetic landscape reshaping and global remodeling of cell identity, structure, basic metabolic processes, and organelle form and function. We hypothesize that variab...

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Vydáno v:Sci Adv
Hlavní autoři: Simic, Milos S., Moehle, Erica A., Schinzel, Robert T., Lorbeer, Franziska K., Halloran, Jonathan J., Heydari, Kartoosh, Sanchez, Melissa, Jullié, Damien, Hockemeyer, Dirk, Dillin, Andrew
Médium: Artigo
Jazyk:Inglês
Vydáno: American Association for the Advancement of Science 2019
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6457941/
https://ncbi.nlm.nih.gov/pubmed/30989118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aaw0025
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