TERT promoter mutations and telomerase reactivation in urothelial cancer

Reactivation of telomerase, the chromosome end-replicating enzyme, drives human cell immortality and cancer. Point mutations in the telomerase reverse transcriptase (TERT) gene promoter occur at high frequency in multiple cancers, including urothelial cancer (UC), but their impact on telomerase func...

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Enregistré dans:
Détails bibliographiques
Publié dans:Science
Auteurs principaux: Borah, Sumit, Xi, Linghe, Zaug, Arthur J., Powell, Natasha M., Dancik, Garrett M., Cohen, Scott, Costello, James C., Theodorescu, Dan, Cech, Thomas R.
Format: Artigo
Langue:Inglês
Publié: 2015
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4640672/
https://ncbi.nlm.nih.gov/pubmed/25722414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1260200
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