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Mutation in TERT separates processivity from anchor-site function
Telomerase shows repeat-addition processivity (RAP): synthesis of multiple telomeric DNA repeats without primer dissociation. Leu14 mutants in the telomerase essential N-terminal domain of Tetrahymena thermophila telomerase reverse transcriptase retain full activity and anchor-site function but lose...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2574958/ https://ncbi.nlm.nih.gov/pubmed/18641663 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1462 |
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