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TERT promoter mutations and telomerase reactivation in urothelial cancer
Reactivation of telomerase, the chromosome end-replicating enzyme, drives human cell immortality and cancer. Point mutations in the telomerase reverse transcriptase (TERT) gene promoter occur at high frequency in multiple cancers, including urothelial cancer (UC), but their impact on telomerase func...
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| Pubblicato in: | Science |
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| Autori principali: | , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4640672/ https://ncbi.nlm.nih.gov/pubmed/25722414 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1260200 |
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