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TERT promoter mutations and telomerase reactivation in urothelial cancer

Reactivation of telomerase, the chromosome end-replicating enzyme, drives human cell immortality and cancer. Point mutations in the telomerase reverse transcriptase (TERT) gene promoter occur at high frequency in multiple cancers, including urothelial cancer (UC), but their impact on telomerase func...

詳細記述

保存先:
書誌詳細
出版年:Science
主要な著者: Borah, Sumit, Xi, Linghe, Zaug, Arthur J., Powell, Natasha M., Dancik, Garrett M., Cohen, Scott, Costello, James C., Theodorescu, Dan, Cech, Thomas R.
フォーマット: Artigo
言語:Inglês
出版事項: 2015
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4640672/
https://ncbi.nlm.nih.gov/pubmed/25722414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1260200
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