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Mutation of the TERT promoter, switch to active chromatin, and monoallelic TERT expression in multiple cancers
Somatic mutations in the promoter of the gene for telomerase reverse transcriptase (TERT) are the most common noncoding mutations in cancer. They are thought to activate telomerase, contributing to proliferative immortality, but the molecular events driving TERT activation are largely unknown. We ob...
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| 出版年: | Genes Dev |
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| 主要な著者: | , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Cold Spring Harbor Laboratory Press
2015
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4647555/ https://ncbi.nlm.nih.gov/pubmed/26515115 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.269498.115 |
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