TERT promoter mutations and monoallelic activation of TERT in cancer

Here we report that promoter mutations in telomerase (TERT), the most common noncoding mutations in cancer, give rise to monoallelic expression of TERT. Through deep RNA sequencing, we find that TERT activation in human cancer cell lines can occur in either mono- or biallelic manner. Without excepti...

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Detalhes bibliográficos
Publicado no:Oncogenesis
Principais autores: Huang, F W, Bielski, C M, Rinne, M L, Hahn, W C, Sellers, W R, Stegmeier, F, Garraway, L A, Kryukov, G V
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Short Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4688396/
https://ncbi.nlm.nih.gov/pubmed/26657580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/oncsis.2015.39
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