TERT promoter mutations and monoallelic activation of TERT in cancer

Here we report that promoter mutations in telomerase (TERT), the most common noncoding mutations in cancer, give rise to monoallelic expression of TERT. Through deep RNA sequencing, we find that TERT activation in human cancer cell lines can occur in either mono- or biallelic manner. Without excepti...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Oncogenesis
Main Authors: Huang, F W, Bielski, C M, Rinne, M L, Hahn, W C, Sellers, W R, Stegmeier, F, Garraway, L A, Kryukov, G V
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2015
Fag:
Short Communication
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4688396/
https://ncbi.nlm.nih.gov/pubmed/26657580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/oncsis.2015.39
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker