TERT promoter mutations in melanoma render TERT expression dependent on MAPK pathway activation

The mechanism of telomerase re-activation in cancer had remained elusive until the discovery of frequent mutations in the promoter of the TERT gene that encodes the catalytic reverse transcriptase subunit of telomerase. We investigated the regulation of TERT expression in melanoma cell lines and our...

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Dades bibliogràfiques
Publicat a:Oncotarget
Autors principals: Vallarelli, Andrelou F., Rachakonda, P. Sivaramakrishna, André, Jocelyne, Heidenreich, Barbara, Riffaud, Laurence, Bensussan, Armand, Kumar, Rajiv, Dumaz, Nicolas
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2016
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5288173/
https://ncbi.nlm.nih.gov/pubmed/27449293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10634
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