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TERT promoter mutations in melanoma render TERT expression dependent on MAPK pathway activation
The mechanism of telomerase re-activation in cancer had remained elusive until the discovery of frequent mutations in the promoter of the TERT gene that encodes the catalytic reverse transcriptase subunit of telomerase. We investigated the regulation of TERT expression in melanoma cell lines and our...
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| 出版年: | Oncotarget |
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| 主要な著者: | , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Impact Journals LLC
2016
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5288173/ https://ncbi.nlm.nih.gov/pubmed/27449293 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10634 |
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