TERT promoter mutations in melanoma render TERT expression dependent on MAPK pathway activation

The mechanism of telomerase re-activation in cancer had remained elusive until the discovery of frequent mutations in the promoter of the TERT gene that encodes the catalytic reverse transcriptase subunit of telomerase. We investigated the regulation of TERT expression in melanoma cell lines and our...

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Опубликовано в: :Oncotarget
Главные авторы: Vallarelli, Andrelou F., Rachakonda, P. Sivaramakrishna, André, Jocelyne, Heidenreich, Barbara, Riffaud, Laurence, Bensussan, Armand, Kumar, Rajiv, Dumaz, Nicolas
Формат: Artigo
Язык:Inglês
Опубликовано: Impact Journals LLC 2016
Предметы:
Research Paper
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5288173/
https://ncbi.nlm.nih.gov/pubmed/27449293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10634
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