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Highly recurrent TERT promoter mutations in human melanoma

Sequencing studies have identified many recurrent coding mutations in human cancer genes; however, highly recurrent mutations involving regulatory regions have rarely been observed. Here we describe two independent mutations within the TERT core promoter that, when taken together, were observed in 7...

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Détails bibliographiques
Publié dans:Science
Auteurs principaux: Huang, Franklin W., Hodis, Eran, Xu, Mary Jue, Kryukov, Gregory V., Chin, Lynda, Garraway, Levi A.
Format: Artigo
Langue:Inglês
Publié: 2013
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4423787/
https://ncbi.nlm.nih.gov/pubmed/23348506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1229259
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