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Interplay between TERT promoter mutations and methylation culminates in chromatin accessibility and TERT expression
The telomerase reverse transcriptase (TERT) gene is responsible for telomere maintenance in germline and stem cells, and is re-expressed in 90% of human cancers. CpG methylation in the TERT promoter (TERTp) was correlated with TERT mRNA expression. Furthermore, two hotspot mutations in TERTp, dubbed...
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| Pubblicato in: | PLoS One |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Public Library of Science
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7141627/ https://ncbi.nlm.nih.gov/pubmed/32267900 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0231418 |
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