Interplay between TERT promoter mutations and methylation culminates in chromatin accessibility and TERT expression

The telomerase reverse transcriptase (TERT) gene is responsible for telomere maintenance in germline and stem cells, and is re-expressed in 90% of human cancers. CpG methylation in the TERT promoter (TERTp) was correlated with TERT mRNA expression. Furthermore, two hotspot mutations in TERTp, dubbed...

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Detaylı Bibliyografya
Yayımlandı:PLoS One
Asıl Yazarlar: Salgado, Catarina, Roelse, Celine, Nell, Rogier, Gruis, Nelleke, van Doorn, Remco, van der Velden, Pieter
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2020
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7141627/
https://ncbi.nlm.nih.gov/pubmed/32267900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0231418
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