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Interplay between TERT promoter mutations and methylation culminates in chromatin accessibility and TERT expression
The telomerase reverse transcriptase (TERT) gene is responsible for telomere maintenance in germline and stem cells, and is re-expressed in 90% of human cancers. CpG methylation in the TERT promoter (TERTp) was correlated with TERT mRNA expression. Furthermore, two hotspot mutations in TERTp, dubbed...
में बचाया:
| में प्रकाशित: | PLoS One |
|---|---|
| मुख्य लेखकों: | , , , , , |
| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
Public Library of Science
2020
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7141627/ https://ncbi.nlm.nih.gov/pubmed/32267900 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0231418 |
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