Severe pegaspargase hypersensitivity reaction rates (grade ≥3) with intravenous infusion vs. intramuscular injection: analysis of 54,280 doses administered to 16,534 patients on children’s oncology group (COG) clinical trials

PEGylated asparaginase (pegaspargase) can be administered via intramuscular (IM) injection or intravenous (IV) infusion with a hypersensitivity reaction (HSR) incidence ranging 3–41%. We evaluated grade ≥3 HSRs when given IM vs. IV on six Children’s Oncology Group (COG) leukemia trials (2003–2015) t...

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Vydáno v:Leuk Lymphoma
Hlavní autoři: Burke, Michael J., Devidas, Meenakshi, Maloney, Kelly, Angiolillo, Anne, Schore, Reuven, Dunsmore, Kimberly, Larsen, Eric, Mattano, Len A., Salzer, Wanda, Winter, Stuart S., Carroll, William, Winick, Naomi J., Loh, Mignon L., Raetz, Elizabeth, Hunger, Stephen P., Bleyer, Archie
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5940583/
https://ncbi.nlm.nih.gov/pubmed/29115886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/10428194.2017.1397658
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