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Severe pegaspargase hypersensitivity reaction rates (grade ≥3) with intravenous infusion vs. intramuscular injection: analysis of 54,280 doses administered to 16,534 patients on children’s oncology group (COG) clinical trials

PEGylated asparaginase (pegaspargase) can be administered via intramuscular (IM) injection or intravenous (IV) infusion with a hypersensitivity reaction (HSR) incidence ranging 3–41%. We evaluated grade ≥3 HSRs when given IM vs. IV on six Children’s Oncology Group (COG) leukemia trials (2003–2015) t...

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發表在:Leuk Lymphoma
Main Authors: Burke, Michael J., Devidas, Meenakshi, Maloney, Kelly, Angiolillo, Anne, Schore, Reuven, Dunsmore, Kimberly, Larsen, Eric, Mattano, Len A., Salzer, Wanda, Winter, Stuart S., Carroll, William, Winick, Naomi J., Loh, Mignon L., Raetz, Elizabeth, Hunger, Stephen P., Bleyer, Archie
格式: Artigo
語言:Inglês
出版: 2017
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5940583/
https://ncbi.nlm.nih.gov/pubmed/29115886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/10428194.2017.1397658
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