Severe pegaspargase hypersensitivity reaction rates (grade ≥3) with intravenous infusion vs. intramuscular injection: analysis of 54,280 doses administered to 16,534 patients on children’s oncology group (COG) clinical trials

PEGylated asparaginase (pegaspargase) can be administered via intramuscular (IM) injection or intravenous (IV) infusion with a hypersensitivity reaction (HSR) incidence ranging 3–41%. We evaluated grade ≥3 HSRs when given IM vs. IV on six Children’s Oncology Group (COG) leukemia trials (2003–2015) t...

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Publicado en:Leuk Lymphoma
Main Authors: Burke, Michael J., Devidas, Meenakshi, Maloney, Kelly, Angiolillo, Anne, Schore, Reuven, Dunsmore, Kimberly, Larsen, Eric, Mattano, Len A., Salzer, Wanda, Winter, Stuart S., Carroll, William, Winick, Naomi J., Loh, Mignon L., Raetz, Elizabeth, Hunger, Stephen P., Bleyer, Archie
Formato: Artigo
Idioma:Inglês
Publicado: 2017
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5940583/
https://ncbi.nlm.nih.gov/pubmed/29115886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/10428194.2017.1397658
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