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Dynamic Consequences of Mutation of Tryptophan 215 in Thrombin
Thrombin normally cleaves fibrinogen to promote coagulation, however, binding of thrombomodulin to thrombin switches the specificity of thrombin toward protein C, triggering the anticoagulation pathway. The W215A thrombin mutant was reported to have decreased activity towards fibrinogen without sign...
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| Publicado en: | Biochemistry |
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| Autores principales: | , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2018
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5940494/ https://ncbi.nlm.nih.gov/pubmed/29634247 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.8b00262 |
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