A protein folding molecular imaging biosensor monitors the effects of drugs that restore mutant p53 structure and its downstream function in glioblastoma cells

Misfolding mutations in the DNA-binding domain of p53 alter its conformation, affecting the efficiency with which it binds to chromatin to regulate target gene expression and cell cycle checkpoint functions in many cancers, including glioblastoma. Small molecule drugs that recover misfolded p53 stru...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Paulmurugan, Ramasamy, Afjei, Rayhaneh, Sekar, Thillai V., Babikir, Husam A., Massoud, Tarik F.
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2018
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5940411/
https://ncbi.nlm.nih.gov/pubmed/29765555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.25138
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