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DDIS-16. A MOLECULAR IMAGING BIOSENSOR MONITORS THE EFFECTS OF ANTI-MISFOLDING DRUGS THAT RESTORE MUTANT p53 FUNCTION AND ENHANCE COMBINATION CHEMOTHERAPY FOR GLIOBLASTOMA
BACKGROUND: Small molecule drugs that induce refolding of mutant p53 conformations may restore tumor suppressor function in glioblastoma. We developed a molecular imaging biosensor to monitor drug modulated changes in p53 folding in cells and in vivo. We evaluated the role of drugs that bind to muta...
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| Publicado no: | Neuro Oncol |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5691978/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.251 |
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