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EXTH-28. TARGETED POLYGIONS ENGINEERED WITH SURFACE miRNAs FOR COMBINED MULTIMODALITY IMAGING AND ENHANCEMENT OF TEMOZOLOMIDE TREATMENT: A NOVEL INTRANASALLY-DELIVERED THERANOSTIC STRATEGY AGAINST GLIOBLASTOMA
INTRODUCTION: We investigate intranasal targeted delivery of theranostic Polyfunctional Gold Iron Oxide Nanoparticles (PolyGIONs) surface loaded with therapeutic microRNAs to allow sensitizing of GBM cells to systemic temozolomide (TMZ), as well as multimodality molecular, anatomic and microscopic i...
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| Udgivet i: | Neuro Oncol |
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| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6847101/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.360 |
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