Intranasal Delivery of Targeted Polyfunctional Gold-Iron Oxide Nanoparticles Loaded with Therapeutic microRNAs for Combined Theranostic Multimodality Imaging and Presensitization of Glioblastoma to Temozolomide

The prognosis for glioblastoma (GBM) remains depressingly low. The biological barriers of the brain present a major challenge to achieving adequate drug concentrations for GBM therapy. To address this, we explore the potential of the nose-to-brain direct transport pathway to bypass the blood-brain b...

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Detalhes bibliográficos
Publicado no:Biomaterials
Main Authors: Sukumar, Uday K., Bose, Rajendran J.C., Malhotra, Meenakshi, Babikir, Husam A., Afjei, Rayhaneh, Robinson, Elise, Zeng, Yitian, Chang, Edwin, Habte, Frezghi, Sinclair, Robert, Gambhir, Sanjiv S., Massoud, Tarik F., Paulmurugan, Ramasamy
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6663564/
https://ncbi.nlm.nih.gov/pubmed/31326657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2019.119342
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