EXTH-61. TARGETED NANOPARTICLE DELIVERY OF THERAPEUTIC ANTIMIR-21 AND ANTIMIR-10B PRESENSITIZES GLIOBLASTOMA TO LOWER EFFECTIVE DOSES OF TEMOZOLOMIDE IN CELLS AND XENOGRAFTS

BACKGROUND: MiR-21 and miR-10b are oncomiRs overexpressed in glioblastoma (GBM). Therapeutic antisense microRNAs (antimiRs) can effectively initiate cellular apoptosis. We hypothesized that encapsulating antimiR-21 and antimiR-10b into c-RGD peptide surface tagged PLGA nanoparticles (NPs) would lead...

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發表在:Neuro Oncol
Main Authors: Malhotra, Meenakshi, Sekar, Thillai, Devulapally, Rammohan, Afjei, Rayhaneh, Paulmurugan, Ramasamy, Massoud, Tarik
格式: Artigo
語言:Inglês
出版: Oxford University Press 2017
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5692759/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.353
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