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EXTH-61. TARGETED NANOPARTICLE DELIVERY OF THERAPEUTIC ANTIMIR-21 AND ANTIMIR-10B PRESENSITIZES GLIOBLASTOMA TO LOWER EFFECTIVE DOSES OF TEMOZOLOMIDE IN CELLS AND XENOGRAFTS
BACKGROUND: MiR-21 and miR-10b are oncomiRs overexpressed in glioblastoma (GBM). Therapeutic antisense microRNAs (antimiRs) can effectively initiate cellular apoptosis. We hypothesized that encapsulating antimiR-21 and antimiR-10b into c-RGD peptide surface tagged PLGA nanoparticles (NPs) would lead...
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| Udgivet i: | Neuro Oncol |
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| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5692759/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.353 |
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