Targeted nanoparticle delivery of therapeutic antisense microRNAs presensitizes glioblastoma cells to lower effective doses of temozolomide in vitro and in a mouse model

Temozolomide (TMZ) chemotherapy for glioblastoma (GBM) is generally well tolerated at standard doses but it can cause side effects. GBMs overexpress microRNA-21 and microRNA-10b, two known oncomiRs that promote cancer development, progression and resistance to drug treatment. We hypothesized that sy...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Malhotra, Meenakshi, Sekar, Thillai Veerapazham, Ananta, Jeyarama S., Devulapally, Rammohan, Afjei, Rayhaneh, Babikir, Husam A., Paulmurugan, Ramasamy, Massoud, Tarik F.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2018
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5940368/
https://ncbi.nlm.nih.gov/pubmed/29765554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.25135
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